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Re: Эритропоэтин при травме?
Caesar Ursic 07 Апрель 2004, 18:55
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To my knowledge, there is no study that shows that by elevating hemoglobin levels with erythropoietin after acute blood loss one actually changes outcome. The Hgb level does rise quicker, but does that actually translate into faster recovery/less death/less complications? I don't think it does. So then, why give it? That is exactly the question that I would politely pose to the erythropoietin sales representatives who used to come to my office to promote their product. They usually smiled sadly and excused themselves.
C.M. Ursic, MD
Sydney
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Re: Эритропоэтин при травме?
Alexander Chelnokov 10 Апрель 2004, 18:57
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CU> elevating hemoglobin levels with erythropoietin after acute blood
CU> loss one actually changes outcome. The Hgb level does rise
CU> quicker,
Is it verified for acute trauma? Any RCT on the topic? AFAIK in adults without severe pre-existed diseases the acute hemorrage activates the endogenous e-poietin. Does additional external one significanly improve at least laboratory criteria like Hb/Ht?
CU> but does that actually translate into faster
CU> recovery/less death/less complications? I don't think it does.
So if somebody does think it does it is enough to give it?
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Re: Эритропоэтин при травме?
Отправитель: Caesar Ursic 10 Апрель 2004, 18:59
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I think you may have inadvertently taken my original post out of context. I was trying to say that there are NO (to my knowledge) studies showing that erythropoietin improves outcome in any significant way in acutely anemic trauma patients.
Erythropoietin may indeed "improve" laboratory criteria like hematocrit/hemoglobin levels, but I doubt that this reduces morbidity or mortality in this patient population. So in my opinion, one cannot justify the use of erythropoietin in acutely anemic trauma patients at this time.
Regards,
C.M. Ursic
Sydney
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